TRPV4 activation by thermal and mechanical stimuli in disease progression
نویسندگان
چکیده
منابع مشابه
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Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-biphosphate (PIP2), although the structural rearrangements occurring on PIP2 binding are currently far from clear. Here we report that activation of the TRP vanilloid 4 (TRPV4) channel by hypotonic and heat stimuli requires PIP2 binding to and rearrangement of the cytosolic tails. Neutralization of the po...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2020
ISSN: 0023-6837,1530-0307
DOI: 10.1038/s41374-019-0362-2